Merseburg is located in the tariff area of the Mitteldeutscher Verkehrsverbund (central Germany transport association).

[4] The rail service was replaced by state bus route 728 operated by Personennahverkehrsgesellschaft Merseburg-Querfurt.

After being interrupted by the First World War, traffic on the line resumed in 1928 and it was finally extended to Leipzig-Leutzsch on 7 July 1931, which gave the station a direct connection to Leipzig.

Merseburg finally got a new station building in 1956, because the former had been destroyed by air raids in the Second World War.

Bombardier Talent 2 electric multiple units have been operated on Regionalbahn line 20 by Abellio Rail Mitteldeutschland since 13 December 2015.