MCC was launched by Mart Godinez in 1963 as an extension branch of Phoenix College and was located at 809 W. Main Street in Mesa.

That same year, MCC's mascot changed from Hokam to Thunderbird, also at this time Helena Howe was appointed president.

The technology building opened in 1984 and was designed by architects Hickman, Schafer & Truley, that same year Wallace A. Simpson became president.

Bar codes were assigned to every item in the library's collection, and appeared on student ID cards for the first time.

In 2004 MCC was visited by then President George W. Bush who discussed his proposal for $250 Million federal grant for job training across the United States.

[5] August 2016, Sasan Poureetezadi was named interim president of Mesa Community College.

Lori Berquam was succeeded by Tammy Robinson July 1, 2022 [6] MCC offers more than 200 degrees, transfer, career and certificate programs.

MCC is one of the largest transfer providers to ASU, while many programs prepare students for immediate entry to the job market.

Additionally, MCC Community Education offers hundreds of non-credit classes providing opportunities for lifelong learning in the arts, technology, fitness and personal development for all age groups.