Mesen-ka (also read as Mesenka) was an ancient Egyptian prince living during the late 2nd Dynasty or at the beginning of the 3rd Dynasty.

It is disputed as to who was the king (pharaoh) that reigned during Mesen-ka's time of officeship.

Mesen-ka is attested by two stone bowl inscriptions only.

These were found in the underground storages beneath the Southern Gallery within the Pyramid of Djoser at Saqqara.

Calligraphic design and diction of the inscriptions show great resemblance to other inscriptions dating back to the time of the kings Peribsen, Khasekhemwy and Djoser.