Mesick (/ˈmiːsɪk/ MEE-sik) is a village in Wexford County in the U.S. state of Michigan.

[4] Mesick was first settled along the Toledo, Ann Arbor and Northern Michigan Railroad within Springville Township in 1890.

The community received a post office on January 9, 1891, with Henry Brooks serving as the first postmaster.

Immediately southeast of Mesick lies Briar Hill, the highest point in Michigan's Lower Peninsula.

[7] As of the census[10] of 2010, there were 394 people, 161 households, and 103 families living in the village.

32.3% of all households were made up of individuals, and 17.4% had someone living alone who was 65 years of age or older.

23.3% of all households were made up of individuals, and 14.5% had someone living alone who was 65 years of age or older.