Mesocco (Lombard: Mesòch) is a municipality in the Moesa Region in the Swiss canton of Graubünden.

The first human settlement in the area dates back to the Mesolithic era.

Stone tools dating to about 6000 BC have been found in the Silex section of the municipality.

A notable necropolis from the early Iron Age (600-500 BC) and traces of a Roman settlement were discovered on Gorda hill near the village.

Additionally, an Early Middle Ages grave (6th century AD) was also discovered on the same hill.

Of the rest of the land, 1.3% is settled (buildings or roads) and the remainder (58.6%) is non-productive (rivers, glaciers or mountains).

It contains the secondary school for the area, the local district courts and numerous government offices.

[5] From the 2000 census[update], 1,093 or 91.0% are Roman Catholic, while 37 or 3.1% belonged to the Swiss Reformed Church.

The wettest month was August during which time Mesocco received an average of 187 mm (7.4 in) of precipitation.

The driest month of the year was February with an average of 60 mm (2.4 in) of precipitation over 6.5 days.

Originally the seat of the noble family von Sax, from the 12th century until 1480 it was held by the Freiherr of Misox.

The church of S. Rocco was built with an attached hospice, which since 1668 has been staffed by the Capuchin friars.