Mesolouri (Greek: Μεσολούρι) is a mountain village and a former community in Grevena regional unit, Western Macedonia, Greece.

The village is surrounded by a verdurous region, full of trees such as beeches, pines, firs, oaks, maples, junipers and other.

The fauna of the area includes animals such as bear, roe deer, wolf, foxes, badgers, squirrels, wild boar, rabbits, and many species of eagles, hawks and other birds.

From the elevations "Petra" (1.326 m), "Tsouka" (1.220 m) and "Krania" (1.237 m) which they are located around the village the view to Kastoria, Grammos, Vintsi, Kissavos and Olympus is fascinating.

Between the elevations "Petra" and "Tsouka" exists a small river which shapes three possessed waterfalls of height 3 m, 2.5 m, and 5 m respectively in distance 1 km NW of village.