[6] At the end of the 19th century, there was a mosque and two Christian churches, while there were Ottoman, Greek and Bulgarian schools.

It holds annual ceremonies on May 19, a day of remembrance for the population, at the Forest of Mesopotamia near the Haliacmon River.

The community of Mesopotamia has recently been linked to a branch of Northern Greece's A2 motorway (Egnatia Odos).

The 1920 Greek census recorded 1,021 people in the village, and 300 inhabitants (140 families) were Muslim in 1923.

[8] In 1945, Greek Foreign Minister Ioannis Politis ordered the compilation of demographic data regarding the Prefecture of Kastoria.

[9] The village Mesopotamia had a total of 1643 inhabitants, and was populated by 700 Slavophones with 80 percent having a Bulgarian national consciousness.