Additional expansions occurred during 1938 and 1939 as a part of the Works Progress Administration created by President Roosevelt.

1954 marked a significant change at MHS when the district relocated all its other existing grade levels to other sites within the city and the campus was solely dedicated to high school education.

Historically, 1954 marked a significant change at MHS when the district relocated all its other existing grade levels to other sites within the city and the campus was solely dedicated to high school education.

[3] This change, however, has not stopped the growth in services MHS offers to its students; Mesquite High School offers a broad array of basic "core classes" revolving around mathematics, English, science, and the social sciences as well as more specialized technical classes such as agriculture, web mastering, automotive technical training, and even cosmotology.

[5] Ranked against the district and the state, MHS falls behind in terms of students successfully meeting the STAAR expectations for the grades 9-11.

[9] The result of much of this has been that MHS enjoys a large number of graduating seniors who attempt either the ACT or SAT prior to applying to a college.

The MHS choral program is considered one of the best in the state[citation needed], placing first division in UIL competitions multiple times in the past several years.