These zones occur because most metamorphic minerals are only stable in certain intervals of temperature and pressure.
[1] The temperature and pressure at which the mineralogical composition of a rock equilibrated can vary laterally through a metamorphic terrane.
Changes in mineralogical composition in a terrane reflect differences in metamorphic grade of the rocks.
The first or last appearance of an index mineral (the place where a metamorphic reaction is observed) forms an easily recognizable isograd.
When mapping the metamorphic grade of a terrane, a geologist has to take the lithology of the rock in account.
The main lithologies are ultramafic, mafic, felsic (or quartzo-feldspathic), pelitic and calcareous.
In this series of zones, both pressure and temperature increase gradually along the metamorphic gradient.