Kidney development

In this region, epithelial cells arrange themselves in a series of tubules called nephrotomes and join laterally with the pronephric duct.

Each mesonephric tubule receives a blood supply from a branch of the aorta, ending in a capillary tuft analogous to the glomerulus of the definitive nephron.

The nephrotomes of the pronephros degenerate while the mesonephric duct extends towards the most caudal end of the embryo, ultimately attaching to the cloaca.

As the cranial end of the bud extends into the intermediate mesoderm, it undergoes a series of branchings to form the collecting duct system of the kidney.

[2] After inducing the metanephric mesenchyme the lower portions of the nephric duct will migrate caudally (downward) and connect with the bladder, thereby forming the ureters.

As the fetus develops, the torso elongates and the kidneys rotate and migrate upwards within the abdomen which causes the length of the ureters to increase.

Diagram shows the sequential development and degeneration of the pronephros and mesonephros, and the induction of the ureteric bud and metanephric mesenchyme during kidney development in mammals.