Eusebius does not mention him in his Church History, probably because he opposed various theories of Origen, thus Jerome provides the earliest accounts of him.

[7] According to him, Methodius suffered martyrdom at Chalcis at the end of the newest persecution, i.e., under Diocletian, Galerius or Maximinus Daia.

Although he then adds, "that some assert", that this may have happened under Decius and Valerian a, this statement (ut alii affirmant), adduced even by him as uncertain, is unlikely, given that Methodius also wrote against the Neoplatonic philosopher Porphyry (234–305).

Like Origen, Methodius is strongly influenced by Plato's philosophy, and uses to a great extent the allegorical explanation of Scripture.

Other authors attributed a work On the Martyrs, and a dialogue Xenon to Methodius; in the latter he opposes the doctrine of Origen on the eternity of the world.

[5]Methodius is seen as an early inspiration of Master Eckhart and Johannes Tauler in William Ralph Inges Bampton Lectures on Christian Mysticism.

(Symposium 1.5)Methodius taught in On the Resurrection that it was to prevent sin from remaining forever that God caused man to become mortal:

For the whole world will be deluged with fire from heaven, and burnt for the purpose of purification and renewal; it will not, however, come to complete ruin and corruption.

But God did not work in vain, or do that which was worst....The creation, then, after being restored to a better and more seemly state, remains, rejoicing and exulting over the children of God at the resurrection; for whose sake it now groans and travails, waiting itself also for our redemption from the corruption of the body, that, when we have risen and shaken off the mortality of the flesh, according to that which is written, " Shake off the dust, and arise, and sit down, O Jerusalem, " [ Isaiah 52:2 ] and have been set free from sin, it also shall be freed from corruption and be subject no longer to vanity, but to righteousness.

[ Isaiah 45:18 ] For in reality God did not establish the universe in vain, or to no purpose but destruction, as those weak-minded men say, but to exist, and be inhabited, and continue.

(chapter 1 paragraph 8 excerpt)Methodius's "Oration on Simeon and Anna" is sometimes quoted as an example of early Christian veneration of Mary as the ever-virgin Mother of God.

O holy Mother of God, remember us, I say, who make our boast in you, and who in august hymns celebrate your memory, which will ever live, and never fade away.

Hail, you city most happy, for glorious things are spoken of you; your priest shall be clothed with righteousness, and your saints shall shout for joy, and your poor shall be satisfied with bread.