Zócalo/Tenochtitlan metro station is located at the heart of the city's downtown, within the vicinity of the National Palace, the Metropolitan Cathedral, and the archaeological remains of Tenochtitlan's main temple, Templo Mayor, among other landmarks.

Inside the station, there is an Internet café, an information desk, a cultural display, a mural titled Cenefas conmemorativas del Bicentenario by Juan Carlos Garcés Botello and Jesús Cristóbal Flores Carmona, and a passageway connecting to Pino Suárez station, which features a free mini-cinema and several bookstores.

[2][3] It is situated in the Cuauhtémoc borough and serves multiple notable landmarks, including Constitution Square (which is locally known as "Zócalo"), the National Palace, the Metropolitan Cathedral, and the archaeological remains of Tenochtitlan's main temple, Templo Mayor.

The remaining two exits serve the northern part of the square: one is next to the Metropolitan Cathedral, and the other is near the National Palace, close to the corner of Calle Moneda.

[5] Inside the station, there is also an information desk and multiple murals titled Cenefas conmemorativas del Bicentenario (2010), created by Juan Carlos Garcés Botello and Jesús Cristóbal Flores Carmona.

The line was subsequently modified to run from Garibaldi to Constitución de 1917 metro stations, following a route beneath Avenida Eje Central.

[16][17] The pictogram represents the coat of arms of Mexico, which depicts an eagle perched on a prickly pear cactus devouring a snake.

[18] In the era of Antonio López de Santa Anna, there were plans to erect a monument dedicated to the Mexican War of Independence at the square.

[18] In August 2020, system authorities updated the station’s signage to "Zócalo/Tenochtitlan" and announced that the change would be formalized in a civic ceremony.

[31][32] The station closed 358 times between 2019 and 31 July 2024—most of the tenure of Andrés Manuel López Obrador as president, with 162 closures resulting from the COVID-19 pandemic.