It is located in the central zone of the Medellín (Colombia) in the Villanueva neighborhood on the north side of Bolívar Park.

Additionally, the temple was formerly called and it is still known but to a lesser extent, as Villaneuva Cathedral, especially during its construction to distinguish it from the Basilica of Our Lady of Candelaria, which was the seat for the Episcopal see at the time.

The cathedral is the principal church of the Roman Catholic Archdiocese of Medellin, home of the Archbishop and Metropolitan Chapter.

In 1948, Pope Pius XII granted the temple the liturgical title of Minor Basilica by papal brief on June 12 of that year.

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