MDC Guaynabo is located next to Fort Buchanan U.S. Army base,[1] and is 6 miles (9.7 km) west of San Juan, the capital of Puerto Rico.

[3] Those 1200 were returned to Guaynabo in the first quarter of 2018, along with other prisoners who had been temporarily held in Atlanta, Georgia, Talladega Alabama, and Miami, Florida.

[4] In 2010, an FBI investigation uncovered a conspiracy to distribute cocaine, heroin, marijuana, Percocet, and Xanax to an inmate at MDC Guaynabo.

Several conspirators, led by Juan Rios-Ortiz, also attempted to provide cellular telephones, chargers, and SIM cards to an inmate of MDC.

[5][6] On February 26, 2013, Osvaldo Albarati, a lieutenant for the Federal Bureau of Prisons, was shot and killed in what is believed to be retaliation for his investigations into cellphone smuggling at MDC Guaynabo.