21 days later, her husband left for the front at the Middle Eastern theatre of World War I to return home only after the conclusion of Armistice of Mudros on October 30, 1918.

As being the spouse of an officer, who was sentenced to death by the Ottoman administration for his involvement in the national resistance, Mevhibe moved together with her family members to her husband's hometown Malatya, and remained there in the years of the struggle.

During the negotiations of the Treaty of Lausanne that lasted eleven weeks from November 1922, she accompanied her husband in Switzerland, who was the head of the Turkish delegation.

Mevhibe İnönü visited several places including Athens, Moscow and Rome as the prime minister's spouse.

[1] She co-founded in 1928 "Yardımsevenler Derneği" (Association of Humanists) and in 1949 "Türk Kadınlar Birliği" (Union of Turkish Women).

[2] Mevhibe İnönü lost on December 25, 1973, her husband, who played a long and important role in the Turkish politics.