Mewgenics is an upcoming tactical role-playing roguelike life simulation video game developed by Edmund McMillen and Tyler Glaiel.

Sent on a journey, the combat portion of the game principally takes place on a procedurally-generated grid with a two-dimensional isometric perspective, where the team must eliminate all the enemies, before advancing.

If a cat loses all its hit points, it will be incapacitated, yet remain in the battle, though it will suffer long-term consequences, such as brain damage – and could still be killed with three subsequent blows from enemies.

[4] Drawing inspiration from The Sims, Pokémon, Animal Crossing and the Tamagotchi, Mew-Genics featured turn-based strategy combat, while leaning heavily into house hub element.

[9] Shortly after production began, McMillen and Refenes realized that they had underestimated the scope of Mew-Genics, with the game experiencing feature creep.

[11] The game was playable for the public at PAX East in Boston, Massachusetts, in April 2014, with Team Meat insisting it would still release that year.

[12] In August 2014, development of Mew-Genics was put on hold, with Refenes stating that the team would be working on refactoring the gameplay to make it more coherent.

[16] While McMillen completed work on The Legend of Bum-bo, the final expansion for The Binding of Isaac: Rebirth called Repentance and the physical card game Tapeworm, Glaiel prototyped several gameplay variants for the rebooted Mewgenics.