Yume is a cheerful first-year junior high school student who by chance caught Mew, a speaking kitten plush who fell from the sky.

They are having their wonderful daily lives when one day, a baby plush kitten called Chia fell from the sky, and they began to take care of her.

Chiaki Kon[6] (Golden Time, Devils and Realist) was to direct the series with Natsumi Murakami be the first cast member to be announced.

[7] On September 10, 2019, a promotional video released by Sanrio's YouTube channel introduced additional characters in the anime.

The directorial role will be filled out by Hiroaki Sakurai (Di Gi Charat, UFO Baby, The Disastrous Life of Saiki K.) instead.

[9] On February 27, 2020, the anime was confirmed to be premiere on April 5, 2020, and more cast members and characters, as well as the theme songs were announced.

[11] A second season, titled Mewkledreamy Mix!, aired from April 11, 2021, to March 27, 2022, with the staff members returning to reprise their roles.

A tie-in manga adaptation is being serialized in two of Kodansha's magazines, Otomodachi and Tanoshii Yōchien, since April 2020 issue.