The novel landed on bestseller lists and Moreno-Garcia's writing has received comparisons to Daphne du Maurier and Guillermo del Toro.

Suspecting that Virgil may be after Catalina's money, Noemí's father, Leocadio, sends her to the Doyle home, High Place, which is located in the mountains outside of a small town named El Triunfo.

During an infrequent visit Catalina begs her to seek out a healer living in the small village near the mansion named Marta Duval and pick up medicine that could save her.

The Doyles use this fungus and remain at High Place, the house infused with the spores of the mushrooms, which has grown inside its walls and all around it, in order to heal themselves and prolong their lives.

Refusing to allow his family to carry out their plans, Francis obtains the medicine Catalina sought out earlier in the novel, as it interferes with the mushroom's abilities.

[4] Moreno-Garcia has also released a book club tie-in that includes a paper doll accompanied by four outfits modeled after the novel's protagonist, Noemí Taboada.

[13][14] NPR drew comparisons between the book and "Jane Eyre, Ann Radcliffe's The Mysteries of Udolpho, Dracula, Rebecca and that 1958 classic sci-fi movie, The Blob", also praising its sense of dread.

[15] The New York Times drew similar comparisons, citing Mexican Gothic's "spunky female protagonist and an ancient house filled with disturbing secrets".

In August 2020 Milojo Productions and ABC Signature announced that they were producing a limited series adaptation of Mexican Gothic, to be released on the streaming platform Hulu.