The current champion is Sanely, who defeated Reyna Isis at Noche de Campeones on September 27, 2024, to win the title.

The first recognized Mexican Women's champion was La Dama Enmascarada who won a tournament in Monterrey in the first half of 1955.

[2] The title would later be won by Irma González on a show held in the el Toreo de Cuatro Caminos bullfighting arena in Naucalpan, State of Mexico.

(the Mexico City Boxing and Wrestling Commission) started licensing female wrestlers to work in Mexico City and officially recognized Reyna Gallegos as the "Mexican National Women's Champion", based on the fact that she was the reigning Mexican Women's Champion, adopting the lineage of the championship retroactively.

[4] The commission allowed Empresa Mexicana de Lucha Libre ("Mexican Wrestling Enterprise") to promote the championship and determine who should challenge or win it.

[4] In 2004 Lady Apache won the championship from Tiffany on an AAA show, and took the title with her when she joined CMLL in 2005.

[6] The current champion is Sanely, who defeated Reyna Isis at Noche de Campeones on September 27, 2024, to win the title.

On occasion single fall title matches have taken place, for example when promoting CMLL title matches in Japan, conforming to the traditions of the local promotion, for instance when Princesa Blanca defended the championship against Lady Apache in Korakuen Hall in Tokyo, Japan.