During the Atlantic slave trade, Portugal and Spain transported many enslaved people from Mozambique to Mexico where they arrived primarily to the port city of Veracruz.

[1] In October 1986, Mexico called for an inquiry into the death of Mozambican President Samora Machel at the United Nations after his plane crashed in South Africa.

In December 2010, Mozambican Minister of the Environment, Alcinda Abreu, paid a visit to Mexico to attend the 2010 United Nations Climate Change Conference in Cancún.

[10] Mexico's main exports to Mozambique include: medicines, chocolates and other candies, trailers and semi-trailers, valves and similar pipes, articles of iron or steel, and fish.

Mozambique's main exports to Mexico include: aluminum cables, titanium ores and their concentrates, data processing machines, clothing, hides, minerals, and precious stones.