The first official diplomatic contacts between Mexico and Portugal took place in 1843 in when ambassadors of both nations met in Washington, D.C., United States.

[2] In July 1991, Portuguese Prime Minister Aníbal Cavaco Silva and President Mario Soares visited the city of Guadalajara, Mexico to attend the first Ibero-American Summit.

During the meeting, both Presidents agreed to boost Portuguese investment in Mexico and for Mexican companies to increase their presence and export products to Portugal.

[6] In February 2024, Mexico signed an agreement with Portugal, and in particular the Coimbra region in an effort to promote business opportunities and encouraging trade and investment between both nations.

[12] Mexico's main exports to Portugal include: unwrought lead, titanium, chemical based products, electronics and telephones, cotton, alcohol, motor vehicles and oil.