Mexico established diplomatic relations with then Czechoslovakia in 1922; four years after the country proclaimed its independence from the Austro-Hungarian Empire.

[1] Initially, Mexico maintained diplomatic relations with Slovakia from its embassy in Prague, however, in 1996 Mexico accredited relations to Slovakia from its embassy in Vienna, Austria due to its close proximity to the Slovak capital of Bratislava.

[10] Mexico's main exports to Slovakia include: auto-parts, machinery, electrical appliances and components, computer memory and copper based products.

Slovakia's main exports to Mexico include: motors and compressors, auto-parts, tractors, electrical appliances and components, tools and tires.

[10] Mexican multinational company Nemak operates a plant in Žiar nad Hronom, Slovakia.