Line 5 has a total of 51 stations and a length of 28.5 kilometers,[2] which runs from northeastern to eastern Mexico City.

[1] Construction of Line 5 started on March 26, 2013 and it was inaugurated on November 5, 2013 by Miguel Ángel Mancera, then-Head of Government of the Federal District.

The second extension added 4 kilometers and 7 stations to the line,[5] serving the Coyoacán, Tlalpan, and Xochimilco boroughs.

[8] Río de los Remedios to San Lázaro Norte Las Bombas to San Lázaro Sur Río de los Remedios to Las Bombas Line 5 services the Gustavo A. Madero, Venustiano Carranza, Iztacalco, Iztapalapa and Coyoacán, Tlalpan and Xochimilco boroughs.

[17] A week before its opening, on September 1, 2020, a truck crashed into Hospital General Troncoso station, damaging the roof.