Mexico participated at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016.

Every participant at the Paralympics has their disability grouped into one of five disability categories; amputation, the condition may be congenital or sustained through injury or illness; cerebral palsy; wheelchair athletes, there is often overlap between this and other categories; visual impairment, including blindness; Les autres, any physical disability that does not fall strictly under one of the other categories, for example dwarfism or multiple sclerosis.

[1][2] Each Paralympic sport then has its own classifications, dependent upon the specific physical demands of competition.

[3] With one pathway for qualification being one highest ranked NPCs on the UCI Para-Cycling male and female Nations Ranking Lists on 31 December 2014, Mexico qualified for the 2016 Summer Paralympics in Rio, assuming they continued to meet all other eligibility requirements.

[8] With one pathway for qualification being having a top finish at the 2014 IBSA Judo World Championships, Mexico earned a qualifying spot in Rio base on the performance of Eduardo Avila Sanchez in the men's -81 kg event.