[5] Mexico fielded a squad of two artistic swimmers to compete in the women's duet event by winning the silver medal at the 2019 Pan American Games in Lima, Peru.

Rio 2016 Olympian Lino Muñoz and debutant Haramara Gaitan were selected to compete in the men's and women's singles respectively based on the BWF World Race to Tokyo Rankings.

[10][11] Mexico national baseball team qualified for the first time at the Olympics by winning the bronze medal over the United States and securing an outright berth as the highest-ranked squad from the Americas at the 2019 WBSC Premier12 in Tokyo, Japan.

With the cancellation of the 2021 Pan American Qualification Tournament in Buenos Aires, Esmeralda Falcón finished among the top five of the women's lightweight category to secure her place in the Mexican squad based on the IOC's Boxing Task Force Rankings for the Americas.

Rogelio Romero (men's light heavyweight) and Brianda Cruz (women's welterweight) completed the nation's sporting lineup by topping the field of boxers vying for qualification from the Americas in the same system.

[18] With the cancellation of the 2021 Pan American Championships, Mexico accepted the invitation from the ICF to send a canoeist in the men's slalom K-1 to the Games, as the highest-ranked eligible nation from the Americas in the federation's international rankings, marking the country's debut in the sporting discipline.

Mexico fielded a squad of three equestrian riders into the Olympic team jumping competition by winning the silver medal and securing second of three available slots at the 2019 Pan American Games in Lima, Peru.

Diego Cervantes claimed a spot in the men's foil by winning the final match at the Pan American Zonal Qualifier in San José, Costa Rica.

[31] Mexico qualified one rhythmic gymnast for the individual all-around by winning the gold medal at the 2021 Pan American Championships in Rio de Janeiro, Brazil, marking the country's debut in this sporting discipline.

Prisca Awiti accepted a continental berth from the Americas as the nation's top-ranked judoka outside of direct qualifying position in the IJF World Ranking List of June 28, 2021.

[34] Mayan Oliver added another women's place on the Mexican squad by finishing among the top eight modern pentathletes vying for qualification in the UIPM World Rankings of 14 June 2021.

[35] On the men's side, Duilio Carrillo and Alvaro Sandoval received the spare berths unused at the 2021 Worlds and previously declined by Ireland's Arthur Lanigan O'Keeffe, as the next highest-ranked, eligible modern pentathletes in the same system.

[36] Mexico qualified one boat in the women's single sculls for the Games by winning the gold medal and securing the first of five berths available at the 2021 FISA Americas Olympic Qualification Regatta in Rio de Janeiro, Brazil.