[citation needed] In 1999, coverage was extended to the east of the Mexican capital, covering the Cuautitlán-Texcoco Valley and the Federal District, by means of XHPTP-TV channel 34 and a broadcast tower atop Three Padres Peak in the municipality of Coacalco.

Some drastic changes in the programming content followed, departing largely from coverage of very local subjects that previously had occupied most of the broadcast schedule.

After the year 2000, Televisión Mexiquense began expansion of its signal to other parts of the Republic and internationally, taking advantage of new technologies and the growing popularity of subscription television.

What syndicated fare it has had over the years has almost exclusively consisted of movies, foreign soap operas (mostly Korean dramas dubbed into Spanish) and cartoons.

On 26 September 2019, Governor Alfredo del Mazo announced that Mexiquense TV would launch two subchannels and a news agency, AMX Noticias.