The earliest evidence of the trade routes passing through Meymeh is the presence of two Seljuk-era rebats in the area.

The 10th-century writer Ibn Khordadbeh described "Rebāṭ-e Vazz" as the station after Borkhvar on the road from Isfahan to Ray (then the main city in the Tehran area).

The name "Vazz" is an apparent reference to Vazvan, indicating that it was originally the main town in the area.

[5] However, Hamdallah Mustawfi, the main authority on Iranian geography in the following 14th century, makes no mention of Meymeh.

By the Safavid era, the main trade route from Isfahan to Tehran had shifted away from Meymeh, now passing through the towns of Natanz, Qohrud, and Kashan in the Kargas mountains.

Meymeh's modern importance came after the automobile gained popularity in Iran, replacing the camel caravans of earlier times.

The arrival of the automobile caused the preferred route to shift from the mountains to the plains of Meymeh and Delijan.

Meymeh also had a carpenter, a blacksmith, a potter, a builder, a brickmaker, a couple of shopkeepers, and two sellers of clothing.

The deputy governor's main responsibility was to preside over the solhiya court that met in Meymeh and was mostly concerned with financial disputes.

Each town also had a kadkhoda, or "head of the village", appointed by the governor of Kashan based on the recommendations of the locals.

To the northwest, the outlying village of Muteh stands isolated on a rural road leading to Golpayegan.

A unique feature of the Meymeh region is the presence of bumkands, which are manmade caverns used to shelter livestock during the harshest part of winter.

Much of modern Meymeh's service economy is dedicated to stores and restaurants along the main highway.