Mezgebu Sime (born 7 October 2005) is an Ethiopian long distance runner.

[1] Mezgebu has won the Ethiopian under-20 title over 5000 metres.

[2][3] He finished sixth at the Great Ethiopian Run in a time of 29:00 in November 2023.

[4] In March 2024, he won silver in the U20 individual and in the team U20 race at the 2024 World Athletics Cross Country Championships in Serbia.

[5] [6]