As a monument of historical literature, the Mezhyhirya Chronicle occupies a significant place in the Ukrainian historiography of the 17th century.
The author writes that the defeat of the latter was associated with the founding of the Chuhuiv Sloboda, as well as the appointment of Polish colonels to Cossack regiments in 1638 (see Ordinance of the Zaporozhian Host [uk]).
The work mentions prominent Ukrainian cultural and church figures Job Boretsky, Petro Mohyla, Sylvester Kosiv, Innocent (Giesel), as well as the names of Polish kings, generals, Muscovite tsars, voivodes, and patriarchs.
The chronicle describes some Tatar-Turkish incursions into Ukraine and the devastation of Poltava, Pereiaslav, Chyhyryn, Kamianets (now Kamianets-Podilskyi), and events that took place in Moscow in the last quarter of the 17th century.
Some stories describe natural disasters: the fire in the Kyiv Castle [uk], dry years, severe frosts, locust invasions, plague, earthquakes, a solar eclipse, etc.