(see below) Yenişehir, another municipality of Mersin, is to the east of Mezitli, Mediterranean Sea is in the south and Toros Mountains in the north.

[5] In the west of Mezitli there are summer houses and coastal villages most of which are specialized in citrus industry.

The ruins of the ancient Greek city of Soli, which was renamed by Roman general Pompey as Pompeipolis (Πομπηιόπολη) is within Mezitli.

In the early 20th century, there was only a small village just north of Soli, named after "Mezitoğlu", an Oghuz tribe.

[6][7] At the 2013 Turkish local government reorganisation, the rural part of the district was integrated into the municipality, the villages becoming neighbourhoods.