Mezyn National Nature Park (Ukrainian: Мезинський національний природний парк) is a national park of Ukraine that covers forest and floodplain terraces of the Desna River in the northern part of the country.

The park was created to balance the protection of sensitive ecological and archaeological sites, recreation, and rural agriculture.

Administratively, the park is in Novhorod-Siverskyi Raion of Chernihiv Oblast, about 150 km north of the regional city of Kharkiv.

This ecoregion is characterized by a mosaic of forests, steppe, and riverine wetlands.

The park features three museums, which can be visited for a small fee: There are a number of hiking trails and campsites.