In Brazil, with the Mi Delirio World Tour, the song was first performed on November 2, 2009, during the participation of the interpreter in the Programa do Jô.

The accompanying music video for "Mi Delirio", directed by Max Gutiérrez, was released on November 17, 2009.

The impact the singer earned two nominations to targeted categories will videos, one for the Premios Juventud and one for Latin Orgullosamente.

The song was written by herself, Gil Cerezo, Ulises Lozano members from Mexican band Kinky and Miguel Blas, it was produced by Gil Cerezo and Ulises Lozano and it's her first solo single since she released her last album Baby Blue in 2000 after almost ten years without a solo album, "Mi Delirio" was performed first time in Premios Juventud 2009 on July 16 in Miami, Florida and was used to close the show.

The story told in the video, and the song is about unrequited love that makes crazy Anahí, causing her to be admitted to a mental hospital.

On January 11, 2010, was released the list of the best clips from the portal POPLine, where Anahí was in the first position, leaving behind singers like Lady Gaga, Rihanna, Beyoncé and Britney Spears.

In the second verse, Anahí appears tied in a table, receiving electroshocks, and in a bed with red sheets wearing all black lingerie through the chorus again.