Shrewsberry attended Cathedral High School in Indianapolis, Indiana, and played collegiately at Hanover College where he was a three-year starter and tri-captain, while leading the league in free throw percentage and assists during the 1998–99 season.

[2][1] While with the Bulldogs, Shrewsberry was part of the program's back-to-back NCAA national runner-up coaching staffs.

[6][7] In just his second season coaching the Nittany Lions, Shrewsberry led the team to a 23–14 record, which saw it finish as runner-up to Purdue in the B1G Tournament and earn its first NCAA Tournament appearance since 2011, where it defeated Texas A&M in the first round and narrowly lost to #2-seed Texas in the round of 32, 71–66.

[8] Shrewsberry collected more Big Ten wins (17) in his first two seasons than any other Penn State head coach.

He was the first-ever full-time coach in IU South Bend men's basketball history, improving in wins in each of his three seasons at the helm of the Titans.

[10] After returning to assistant coaching with successful stints at Purdue (2011–13, 2019–21) and in the NBA with the Boston Celtics (2013–19), Shrewsberry took over the Penn State men's basketball program in March 2021.