[2] For three years after earning his Ph.D., Amiridis worked as a research engineer at W.R. Grace and Co., an international manufacturer of specialty chemicals and materials, in Columbia, Maryland, and taught for a semester at Johns Hopkins University in Baltimore.

[6] As provost at USC, Amiridis led efforts for growth in student enrollment, with significant improvement in the quality of the undergraduate class.

He initiated an ambitious faculty hiring program, creating 200 new tenure positions in a four-year period, and developed an academic dashboard to monitor success.

During his tenure, UIC achieved historic highs in student enrollments (34,000) and annual research awards ($450 million), initiated an ambitious capital program to renew its infrastructure, initiated and completed a $750 million capital campaign, and acquired the John Marshall School of Law, which became the first public law school in the history of Chicago.

He also served on the board of directors of the Chicago Council on Global Affairs and the Chicagoland Chamber of Commerce and was appointed by governor-elect J.B. Pritzker to his Educational Transition Committee.

In October 2022, HACU honored him with the President's Award of Excellence for his efforts to diversify UIC's senior leadership and to create opportunities for Hispanic students.