He is the author of several books on cultural studies, disability rights, liberal and conservative politics, and debates in higher education.
Bérubé held a professorship in the English department at the University of Illinois at Urbana–Champaign from 1989 to 2001, where he was affiliated with the Unit for Criticism and Interpretive Theory and the Afro-American Studies and Research Program.
He now co-edits "Crip: New Directions in Disability Studies" for NYU Press along with Robert McRuer and Ellen Samuels.
[citation needed] Bérubé's third book, Life As We Know It: A Father, A Family, and an Exceptional Child, was published in 1996.
Bérubé also published a number of essays critical of figures on the antiwar left and their response to the terrorist attack of 9/11 and the invasion of Afghanistan, though he said he opposed the Iraq War; the argument was elaborated in his seventh book, The Left At War, published in 2009.
[citation needed] Bérubé lives in State College, Pennsylvania, with his wife Janet Lyon.