[1] In 1650, the Protestant royalists in Ireland employed Boyle, in conjunction with Sir Robert Sterling and Colonel John Daniel, to negotiate on their behalf with Oliver Cromwell.

In addition to the episcopal revenues, he continued to receive for a time the profits of six parishes in his diocese, on the ground of being unable to find clergymen for them.

[1] Though the appointment of a cleric as Lord Chancellor had previously been common, Boyle's was the last such appointment and it appears he was offered the position only because no professional lawyer of repute could be found to take it: the aged and ineffective Sir Maurice Eustace had remained in office as Chancellor until his death simply because of the difficulty in finding a suitable replacement.

While he undoubtedly used his influence to advance the career of his son-in-law, Sir William Davys, who was appointed Lord Chief Justice of Ireland in 1680, such use of patronage was an accepted part of seventeenth-century politics.

Clarendon had formed a very high opinion of Boyle, and is said to have objected to his dismissal from the Chancellorship, despite his lack of legal training, and his increasing infirmities, of both body and mind.

Boyle chose to live in his newly acquired Wicklow estate and was granted a royal charter to establish a new town there on a greenfield site, which he named Blessington – or Blesinton as it was more commonly referred to during the 1600-1800s.

George Synge, Bishop of Cloyne and his first wife Anne Edgeworth: she died in a shipwreck in 1641, along with their infant daughter Martha.

In addition to his son, who was created Lord Blessington, he had six daughters by his second marriage, named Elizabeth, Mary (who died young), Margaret, Eleanor, Martha, and Honora.

Elizabeth married Denny Muschamp of Horsely, Surrey, the Muster Master-General for Ireland, and was the grandmother of John Vesey, 1st Baron Knapton.