After Conforto played college baseball for the Oregon State Beavers, the Mets selected him in the first round of the 2014 MLB draft with the 10th overall pick.

[19] Prior to the 2014 season, he was named the preseason Sporting News College Baseball Player of the Year.

[26] He played for the Brooklyn Cyclones of the Class A-Short Season New York–Penn League after he signed.

[30] On July 12, 2015, at Great American Ball Park in Cincinnati, he started in left field for the United States team at the All-Star Futures Game and collected two hits and one assist.

[31] He was named an FSL Mid-Season All Star, and to the 2015 Topps Rookie All-Star team.

[34] He made his debut later that day, picking up his first major league RBI on a groundout, but going 0-for-3 while becoming the 1,000th player to appear in a game for the Mets.

[36] He hit his first major-league home run on August 3 off Marlins' starter Tom Koehler.

On June 25, the Mets demoted Conforto to the Las Vegas 51s of the Class AAA Pacific Coast League and called up Brandon Nimmo.

[43] After his return to the Mets, Conforto began playing both corner outfield positions.

He made his major league debut in center field on July 23, 2016, as a defensive replacement.

[45] On August 24, during a game against the Arizona Diamondbacks, Conforto suffered a season-ending injury during a swing, as he dislocated his left shoulder and tore his posterior capsule.

[49] On April 8, 2021, Conforto was the batter during a rare walk-off hit by pitch to win a game against the Miami Marlins.

[52] The 2021–22 Major League Baseball lockout delayed free agency talks that offseason.

His agent, Scott Boras, later released a statement saying that an offseason shoulder injury suffered in January 2022 during a workout resulted in Conforto not starting the season with a contract.

On January 6, 2023, Conforto signed a two-year contract worth $36 million with the San Francisco Giants, containing an opt-out clause after the first season.

[59] In his two seasons with the Giants, Conforto compiled 35 home runs, a .238 batting average, .740 OPS, and 108 OPS+ in 255 games played.

[40] On December 10, 2024, Conforto signed a one-year, $17 million contract with the Los Angeles Dodgers.

[60] Conforto's mother, Tracie Conforto (née Ruiz), is a three-time Olympic medalist in synchronized swimming,[61] and his father, Mike, an Italian American,[62] played inside linebacker at Penn State.