[citation needed] Knox's career has spanned the fields and topics of death and dying, community mental health, ethics, the prevention of HIV/AIDS, and peace.

As a tenured professor, he served on dissertation committees and taught courses including "Honors Seminar in Applied Ethics", "Death and Dying", and "HIV and Mental Health".

He has published and presented widely,[peacock prose] primarily on the topics of HIV/AIDS, peace, community mental health, and planning for death.

He is the senior editor and contributor to HIV and Community Mental Healthcare,[5] a book published in 1998 by The Johns Hopkins University Press.

He was elected chair of the Advisory Council of Faculty Senates for 1997/1998, an organization that represented all ten state universities and provided consultation to the chancellor and Florida Board of Regents regarding academic issues.

In 1999, as part of a sabbatical assignment related to end-of-life care, he served as a visiting scholar at the University of Oxford in England.

He was co-chair of the American Foundation for AIDS Research's 16th National HIV/AIDS Update Conference held in March 2004 and delivered an opening plenary arguing against current US wars in favor of more government support for prevention.

[2] As a delegate to the 20th National Student Congress, he introduced a successful resolution to hold an anti-war demonstration in August 1967 in front of the White House.