Michael Edwin Keefe (April 14, 1844 – June 28, 1933) was a building contractor and political figure in Nova Scotia, Canada.
He represented Halifax County in the Nova Scotia House of Assembly from 1900 to 1906.
He was born in Halifax, the son of John Keefe, of Irish descent.
Keefe served as mayor of Halifax from 1892 to 1895.
He ran unsuccessfully for a seat in the House of Commons in 1896.