He has been a professional musician since the 1970s, most notably in Hot Tuna, the New Riders of the Purple Sage, and the Memphis Pilgrims, a Memphis-style rock and roll/blues band that he founded in 1986.

A re-released version of the song "Last Train Out," which he wrote in memory of the Allman Brothers Band and Gov't Mule bass player Allen Woody, appears on the record.

Blues Planet re-released Mecca,[5] an album that Falzarano and the Memphis Pilgrims originally released in 1996 on Relix Records with guests Jorma Kaukonen, Pete Sears, and Harvey Sorgen of Hot Tuna and Danny Louis of Gov't Mule.

Falzarano also produces other artists, and teaches guitar workshops at Jorma Kaukonen's Fur Peace Ranch.

In 2013, Falzarano's original composition "When There's Two There's Trouble" was featured in Alexandre Moors' critically acclaimed film Blue Caprice with Isaiah Washington, Tim Blake Nelson, and Joey Lauren Adams.