As an actor, Hitchcock has appeared in several of Christopher Guest's critically acclaimed movies, including Waiting for Guffman (1996), Best in Show (2000),[1] A Mighty Wind (2003), For Your Consideration (2006), and Mascots (2016).

(2024), Reunion (2024), EXmas (2023), Your Place or Mine (2023), Barb and Star Go to Vista Del Mar (2021), Magic Camp (2020), Bridesmaids (2011), Super 8 (2011), Operation: Endgame (2010), Smiley Face, Wild Hogs (2007), Joss Whedon's Serenity (2005), Pretty Persuasion (2005), Bug (2002), Heartbreakers (2001), and Happy, Texas (1999).

[2][3] Other roles in television series include Palm Royale, A League of Their Own, Space Force, The Goldbergs, People of Earth, Veep, Curb Your Enthusiasm, Nobodies, Idiotsitter, Tom Goes to the Mayor, Up All Night, Entourage, The League, The Glee Project, Pushing Daisies, Arrested Development, Head Case, The Suite Life on Deck, Las Vegas, and Desperate Housewives.

[2] Hitchcock's other writing credits include the comedy films House Arrest (1996), and The Ultimate Christmas Present (2000) as well as the critically acclaimed drama Where the Day Takes You (1992), which marked the film acting debut of Will Smith and also featured Dermot Mulroney, Lara Flynn Boyle, Sean Astin, Balthazar Getty, and Christian Slater.

Hitchcock is an alumnus of The Groundlings, a Los Angeles-based improvisational and sketch comedy theater troupe.