In the early 1970s Lomawywesa founded, with painters Neil David Sr, Milland Lomakema, Delbridge Honanie and Terrance Talaswaima, a group called Artist Hopid which was dedicated to new interpretation of traditional Hopi art forms.

His paintings and silverwork have an organic graffiti-like quality with dynamic motion and symbolism, with a rich color palette on canvas and an added dimension when rendered in silver.

In his paintings, Lomawywesa combined traditional kiva murals, figures from Hopi oral history, motifs present in Pueblo Native basketry and embroidery, and contemporary elements of design.

[6] Particularly interested in the Tricksters and Clowns of Hopi history, Lomawywesa thought it important to express their purpose of bringing about harmony through the exposure of human folly and imperfection.

[1][6] Lomawywesa's work, especially that in conjunction with his group Artist Hopid, has been compared to that of Pablo Picasso, Georges Braque, Fernand Léger, and Vasily Kandinsky for its visual similarities to cubism and expressionism.

Lomawywesa stated that both he and Artist Hopid drew from early Puebloan painters, only that they abstracted the same thematic elements of dance and song, emphasizing the motion within traditional Hopi ceremonies.

[2][8] Utilizing the techniques he practiced in his jewelry work, he designed the front gate for the Heard's Berlin Gallery and the Museum of Northern Arizona.