[2] She began her career on stage before appearing opposite Wesley Snipes in the 1991 film New Jack City.
In the 1990s, Michele had leading roles in two CBS television series: crime drama Dangerous Curves (1992–93) and prime time soap opera Central Park West.
In 1989 she sued actor Eddie Murphy in a high-profile Hollywood lawsuit alleging she was fired from the movie Harlem Nights for rejecting his romantic advances.
[6] In 1991, Michele had a starring role opposite Wesley Snipes in the 1991 film New Jack City directed by Mario Van Peebles.
She left the show in early 1995 to play one of the leads in the CBS prime time soap opera Central Park West alongside Mädchen Amick, Lauren Hutton and Raquel Welch.
[citation needed] She later had two more movie roles: crime drama Dark Blue (2002) and romantic comedy How to Lose a Guy in 10 Days (2003).
[8] She returned to television in 2004, with a starring role in the short-lived UPN legal drama series Kevin Hill opposite Taye Diggs.
In 2007, she guest starred on Law & Order: Special Victims Unit and in two episodes of House as a doctor who had previously worked with the CIA.
In 2009, Michele starred in the Hallmark Channel film Relative Stranger with fellow ER cast member Eriq La Salle.
In 2017, Michele returned to series regular work playing villainous Ayanna Floyd, president of the record label, in the Fox prime time soap opera Star.