He founded and directed for 30 years a non-profit organization called Ground Zero Minnesota dedicated to "top-quality, non-partisan education for informed democracy and human survival."

Andregg has published numerous articles, study guides, documentaries and papers on biology, genetics, technology and contemporary social problems related to armed conflict.

During his university career, Andregg conducted field research on the behaviors of Barbary Apes (Macaca sylvanus) in the Atlas Mountains of Morocco and co-authored several articles with his mentor Dobzhansky, including "Distribution Among the Chromosomes of Drosophila pseudoobscura of the Genes Governing the Response to Light".

Andregg's study of global armed conflict and genocide resulted in his book, On the Causes of War, which won the International PeaceWriting Award in 1999, was reprinted twice, republished in Canada and translated into Italian.

In 2008, he acted as a liaison between peace activists and the local police department during the Republican National Convention, held in Saint Paul, Minnesota.