His books are Downtown and Manhattan on the Rocks, as well as a compilation of selected columns published as La Dolce Musto: Writings By The World's Most Outrageous Columnist and a subsequent collection, Fork on the Left, Knife in the Back.

[5] Musto's breathlessly dishy and opinionated first-person column celebrated nightlife and LGBT personalities, described outlandish New York club fetes, and gave vital early coverage to up-and-coming performers like John Sex, RuPaul, Kiki and Herb, Bridget Everett, Jackie Hoffman, Bianca Del Rio and Peppermint.

A 1989 appearance in Slaves of New York—based on Tama Janowitz's book centered on the New York nightlife scene—was called the film's only moment of credibility by critic J. Hoberman of The Village Voice.

He has also done cameos in videos by TV on the Radio, Sherry Vine, Sharon Needles, Jinkx Monsoon, Larry Tee, and Gorgon City featuring Jennifer Hudson, among many others.

Musto penned several writeups in The Village Voice about the 1996 murder of Andre "Angel" Melendez, helping bring national attention to a case that resulted in the trial and conviction of Michael Alig and Robert "Freeze" Riggs.

Discussing topics like gossip and nightlife, Musto also appeared on daytime talk shows hosted by Sally Jessy Raphael, Joan Rivers, Ricki Lake, Richard Bey, Gordon Elliott, and Mark L. Walberg.

In 2010, Musto made a cameo appearance in Erasure's re-release of A Little Respect (HMI Redux)';[6] the proceeds of this release were donated to help students attending the Harvey Milk Institute.

That year, Musto also added "Theater Producer" to his resume, when he coproduced the musical comedy Perfect Harmony about the search for truth, love, and high school a cappella championship glory, which played Off-Broadway in New York City.

Musto was a regular commentator on MSNBC's Countdown with Keith Olbermann where he sardonically skewered the antics of Paris Hilton, Lindsay Lohan, and other scandalous celebrities du jour.

He played a lead role and received rave reviews from Eileen Shapiro of Huffington Post,[citation needed] for the film Vamp Bikers Tres by Eric Rivas, as a head doctor named Hedda Hopper alongside Angel Salazar.

The roast which was produced by Daniel DeMello and directed by Rachel Klein, featured Bianca Del Rio, Jinkx Monsoon, Judy Gold, Orfeh, Randy Rainbow, and Luann de Lesseps.