Although his radio delivery is mainly characterized as politically themed, he also often covers topics such as medicine, nutrition, music, literature, history, theology, philosophy, sports, business, economics, and culture, and tells personal anecdotes.

[24] Another turning point occurred for him as a writer of health and nutrition books in the 1980s, when he experienced what he saw as "political opposition" after making the suggestion that the closure of homosexual bathhouses might be necessary in response to the emerging HIV/AIDS epidemic.

[27] The rejection by publishers of his 1994 manuscript about illegal immigration and epidemics prompted Savage to record a demo tape with a mock radio talk show about the contents of the work.

He has described his show's production as one with a "... hard edge combined with humor and education ... Those who listen to me say they hear a bit of Plato, Henry Miller, Jack Kerouac, Moses, Jesus, and Frankenstein.

"[11] By 2009, The Savage Nation had an audience of 8 to 10 million listeners on 400 stations across the United States, making it the second most listened-to radio talk show in the country at the time.

[36] John Scott, program director of KNEW said in an email that the station was headed "... in a different philosophical and ideological direction, featuring more contemporary content and more local information.

[38] On January 22, 2010, Savage revealed to his audience that a writer for Playboy had contacted him via email to do a lengthy interview, and again asked his listeners if he should accept the offer.

[55] In August 2019, following the Trump administration's reauthorization of the use of cyanide bombs against wild animals,[56] Savage called on the White House and the US Environmental Protection Agency to reverse approval.

[18] On March 28, 2006, following pro-immigration rallies in California, he encouraged his listeners to burn Mexican flags as an act of American nationalism to protest illegal immigration from Mexico.

risks igniting a civil war to gain total control of the population for their plans of "a new Soviet-style superstate, which have been long on the drawing books.

On February 13, the first day it was reported in the news, "Savage used his radio show to attack the transfer of American homeland assets to a company owned by an Arab state.

"[66] Savage and other opponents of the deal "generated a wave of anger from Americans across the country that left lawmakers in Washington -- by their own admission -- following their constituents much more than leading them."

Congressional offices on Capitol Hill were deluged by phone calls and emails protesting the deal, and congressmen told of being pulled aside wherever they went in their districts.

On his radio show Savage used his credentials—a PhD with training in epidemiology—to speak to his fans on coronavirus research: How the virus is transmitted; which treatments were proving effective; and the difference between morbidity and mortality rates.

"[74] Savage is also sharply critical of the Director of the NIAID, Dr. Anthony Fauci, dismissing him as "a grandstander" who mishandled the AIDS epidemic by refusing to close down the gay bathhouses.

A 2013 Ethics Alarms article recounts Savage saying that "...one of his heroes growing up was Jonas Salk, not because he invented the first effective polio vaccine, but because he refused to patent it, and gave it to the world for the benefit of humanity.

"[50] Various progressive advocacy groups such as GLAAD and FAIR accuse Savage of racism, homophobia, transphobia, and Islamophobia because of his controversial statements about homosexuality, Islam, feminism, sex education, and immigration.

[95] In March 2006, Savage criticised Roman Catholic assistance to illegal immigrants (in response to statements by Cardinal Roger Mahony of Los Angeles calling it "pastoral support").

"[98] On November 5, 2007, following a campaign by CAIR meant to get Savage off the air by alerting his sponsors to the nature of his comments, Citrix Systems, Inc. pulled its advertisements from his show.

[101] On July 25, 2008, United States district court Judge Susan Illston dismissed Savage's suit against CAIR, holding that the posting of the audio clip was protected under fair use.

[104] In July 2008, Savage said that the increasing rate of autism diagnoses was the result of "a racket" designed to get disability payments for "poorer families who have found a new way to be parasites on the government.

"[106]Also in July 2008, the progressive pressure group Media Matters for America picketed the studios of WOR in New York, along with parents of autistic children.

"[105] Also that day, the insurance company Aflac pulled its advertising,[108] and the Supertalk Mississippi radio network dropped Savage's program, replacing it with The Dennis Miller Show.

[105] On July 25, 2008, Autism United advocates gathered to announce that several advertisers, including RadioShack, Sears, The Home Depot, and DirectBuy, would discontinue their support for Savage's show.

[111] On May 5, 2009, it was announced by then-Home Secretary Jacqui Smith of the Labour party that Savage was on a list of people banned from entering the United Kingdom as he is "considered to be engaging in unacceptable behaviour by seeking to provoke others to serious criminal acts and fostering hatred which might lead to inter-community violence".

[116] During a subsequent NPR talk show, Savage said that he has never advocated violence and repeatedly invoked the United States Constitution's First Amendment.

[120][121] In The Guardian, Catherine Bennett wrote: "The ban on Savage is so far from being a comprehensible act, so staggeringly capricious and stupid, as to defy evaluation.

In January 2004, Savage published his second political book The Enemy Within: Saving America from the Liberal Assault on Our Schools, Faith, and Military.

Released through the HarperCollins imprint of William Morrow and Company, Savage argues in the book that "Americans are boiling mad over the way Congress and this Marxist/Leninist-oriented President are manipulating the current economic crisis to nationalize businesses.

[145] In it he discusses what he calls the many "loud flashpoints" that he believes have engulfed American thought over the nation's history, and relates those phenomena to what he describes as a current obsession with Trump hatred.