He has also appeared as a guest star on Cold Case, Without a Trace, Bones, The Mentalist as Bradon Fulton in season 1 episode 19 and Commander in Chief.

In 2008, Trevino was cast for a three-episode arc on The CW's 90210, playing Ozzie, a student at West Beverly Hills High School and love interest for Naomi.

In April 2015, it was announced that Trevino would be leaving The Vampire Diaries after the end of the sixth season, like his co-star Nina Dobrev.

[11][12] From 2019, Trevino began starring in the CW's Roswell, New Mexico as Kyle Valenti, a doctor and the son of the sheriff.

[17] Together with his The Vampire Diaries co-stars Candice Accola and Ian Somerhalder, Trevino supports the It Gets Better Project, which makes it a goal to prevent suicide among LGBT youth.