He has published over 150 articles in medical and scientific journals on the damaging effects of second-hand smoke, lead exposure, and countless other determinants of children's health and behavior.

He currently is a professor at New York University with appointments in the departments of pediatrics, environmental medicine, and global public health.

[12] Weitzman's tobacco-related work, which includes more than 40 research papers over the past 25 years, has been central to the recognition of the effects or contribution of prenatal tobacco and childhood secondhand smoke exposure, including associations with increase rates of childhood asthma, child mental health and school problems, parental physical and mental health problems and the negative effects of these problems on child health and food insecurity among children of smokers, increased rates of tooth decay and the metabolic syndrome, and most recently, increased rates of sensorineural hearing loss.

[14] Weitzman was a key witness as part of the Department of Justice's federal racketeering case against the tobacco industry.

[15][16][17] Currently he serves on the Scientific Advisory Committee for the Food and Drug Administration's (FDA) Tobacco Center.

Weitzman's research has also focused on the ways in which malnutrition and food insecurity produce profound effects on child health and development.