Przysiężny made a return from a knee injury qualifying as a lucky loser in the 2008 Swedish Open; however, he lost to Jonas Björkman in the first round and winning Davis Cup matches.

Three months later, he won another Challenger tournament, where he eliminated Andrey Kuznetsov, Evgeny Kirillov, Goran Tošić, Tobias Kamke, and Julian Reister in the final.

The week of March 29, he won matches against Caio Zampieri, Laurynas Grigelis, Charles-Antoine Brézac, Teymuraz Gabashvili, and Rubén Ramírez Hidalgo in the final of the Saint–Brieuc Challenger.

Przysiężny scored the biggest win of his career, defeating the Croatian in straight sets, subsequently losing in the second round to eventual quarterfinalist Yen-Hsun Lu.

At the 2013 St. Petersburg Open he defeated Albert Ramos, Fabio Fognini and Lukáš Rosol to reach semifinals, where he lost to Ernests Gulbis.

In doubles he partnered with Pierre-Hugues Herbert, defeating the Bryan brothers, Jamie Murray / John Peers, Eric Butorac / Raven Klaasen and Ivan Dodig / Marcelo Melo to claim the title.