Michalovce (pronunciationⓘ; Hungarian: Nagymihály, German: Großmichel, Romani: Mihalya, Yiddish: מיכאלאָווצע Mikhaylovets or Mykhaylovyts; Ukrainian: Михайлівці) is a town on the Laborec river in eastern Slovakia.

Originally named after the Archangel St Michael,[4] it is the second-largest city in the Košice Region and the seat of the Michalovce District.

The city is located on the shore of Lake Sirava, approximately 360 kilometres (224 miles) east of the capital Bratislava and immediately adjacent to the border with Ukraine.

Michalovce is mostly recognized for its adjacent lakes and volcanic mountains, which generates tourism, and for agriculture as well as the passing Druzhba pipeline.

Archaeologists have found prehistoric Homo sapiens skeletons in the region, as well as numerous objects and vestiges by the foot of the Vihorlat mountains, dating from the Neolithic.

The history of Michalovce was significantly influenced by presence of Celtic tribes, starting from the Gallic expansions in the 4th century BC, and later by the Romans.

Since the Austrian-Hungarian Ausgleich of 1867, it achieved the status of a large community, and shortly afterward became the seat of one of the districts of Zemplén County.

Many left to seek work in the coal mining industry in Pennsylvania, United States, giving rise to a large Rusyn American community there.

The previous agricultural character of Michalovce was changed by a number of newly established industrial factories after 1945.

The town lies in the Košice Region, in the Eastern Slovak Lowland on the Laborec river, historically belonging to Zemplén County.

The largest health care provider in the municipality is the Štefan Kukura Hospital in Michalovce, with 712 beds.